Cenforce-d Brand

Cenforce-D® is produced by Centurion. It is a combined medication that prevents men from ejaculating prematurely and helps to sustain an erection long enough for normal, satisfying sexual intercourse. Cenforce-D® contains two active ingredients – Sildenafil, a phosphodiesterase type 5 inhibitor, and Dapoxetine, short-acting serotonin reuptake inhibitor (SSRI).

Indications:

- erectile dysfunction or impotence;

- prematurity of ejaculation (PE).

Sildenafil is approved for the treatment of PAH (pulmonary arterial hypertension).

MOA (mechanism of action):

Sildenafil suppresses the enzyme phosphodiesterase type 5 (PDE-5). PDE-5 usually breaks down chemical messenger called cyclic GMP, which normally widens the blood vessels in the penis by relaxing muscles in the blood vessel walls. This delivers more blood to the penis, inducing a rigid erection. When the PDE-5 is inhibited, blood vessels are kept dilated longer, which improves blood flow to the penis and helps maintain an erection. Dapoxetine increases the activity of serotonin, a neurotransmitter that is involved in passing messages between nerve cells, including those that result in ejaculation. Enhanced activity of serotonin aids in increasing the time it takes to ejaculate and improves control over the ejaculation. Initially, Dapoxetine was created as an antidepressant.

Dosage

Swallow a pill whole with a drink of water.

Take one pill of Cenforce-D® orally 1 hour prior sexual activity.

Precautions:

Cenforce-D® pills are best taken with food.

Avoid consuming products containing grapefruit, as it may interfere with the medication's effectiveness.

Cenforce-D® does not protect you or your partner from sexually transmitted diseases (including HIV) or from pregnancy.

Take Cenforce-D® tablet not more than once every 24 hours.

It should only be taken when sexual activity is anticipated and is not intended as a regular treatment that is taken each day.

Missing a dose

Cenforce-D® is used only when needed, therefore missed dosages are not relevant. Do not exceed the doctor's recommended dose. Do not take a double dose.

Overdose

If you take an overdose of Cenforce-D®, you should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Cenforce-D® are:

• dizziness
• headache
• feeling sick
• anxiety, irritability, restlessness or agitation
• difficulty concentrating
• difficulty sleeping
• feeling tired or sleepy
• yawning
• tremor
• tinnitus
• blurred vision
• sinus congestion
• upset stomach
• indigestion, flatulence and dry mouth
• excessive sweating
• flushing

Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Cenforce-D® if you are allergic to Sildenafil, Dapoxetine, other PDE-5 inhibitors (Tadalafil, Vardenafil, Udenafil), other SSRIs or to any of the medication's components.

Do not take Cenforce-D® if you have taken recreational drugs such as ecstasy (MDMA), ketamine, LSD, poppers (amyl nitrate), narcotics or benzodiazepines.

Do not take Cenforce-D® if you are taking erythromycin, alpha-blockers, antifungal medications (ketoconazole and itraconazole), medications for HIV (ritonavir, saquinavir, nelfinavir and atazanavir), certain antibiotics (telithromycin), lithium, antidepressants (venlafaxine, fluoxetine).

Do not take Cenforce-D® if you if you experience seizures (convulsions or fits).

Try not to consume alcohol while using Cenforce-D®, as it can lower your blood pressure, causing dizziness and rapid heart rate (tachycardia).

Be careful with Cenforce-D® if you have heart issues, cardiovascular disease or a history of heart attacks; liver or kidney disorders; low blood pressure (hypotension).

Do not take Cenforce-D® if you have a history of fainting, mania (feeling overexcited, irritable or not being able to think clearly) or severe depression.

Cenforce-D® is not for use in women, children or adolescents under age 18 years.

Q: What is Cenforce-D®?

A: Cenforce-D® is anti-impotence drug usually taken to manage erectile dysfunction (inability to achieve or maintain erection) and control ejaculation if it occurs too rapidly (within 1 minute after penetration). Cenforce-D® starts working in 1 hour after administration. Suitable for individuals over 18 years of age.

Q: How does Cenforce-D® work?

A: Sildenafil acts by stimulating the release of nitric oxide (NO) in response to sexual arousal in men. NO in its turn activates the lyase enzyme which is followed by increasing levels of cyclic guanosine monophosphate (cGMP). This relaxes smooth muscles in blood vessels of penis, increasing blood flow and thus inducing an erection. Dapoxetine works by increasing the activity of serotonin in the nervous system. Serotonin is a neurotransmitter that is involved in passing messages between nerve cells, including those that result in ejaculation. Promoting the activity of serotonin aids in increasing the time it takes to ejaculate and improves control over the ejaculation. Initially, Dapoxetine was created as an antidepressant.

Q: When should I not use Cenforce-D®?

A: Do not take Cenforce-D® if you are allergic to Sildenafil, Dapoxetine, other PDE-5 inhibitors (Tadalafil, Vardenafil, Udenafil), other SSRIs or to any of the medication's components. A full list of contraindications learn in the section Safety Info.